DNA repair fidelity in stem cell maintenance, health, and disease

Chinnadurai Mani, P. Hemachandra Reddy, Komaraiah Palle

    Research output: Contribution to journalReview articlepeer-review

    26 Scopus citations


    Stem cells are a sub population of cell types that form the foundation of our body, and have the potential to replicate, replenish and repair limitlessly to maintain the tissue and organ homeostasis. Increased lifetime and frequent replication set them vulnerable for both exogenous and endogenous agents-induced DNA damage compared to normal cells. To counter these damages and preserve genetic information, stem cells have evolved with various DNA damage response and repair mechanisms. Furthermore, upon experiencing irreparable DNA damage, stem cells mostly prefer early senescence or apoptosis to avoid the accumulation of damages. However, the failure of these mechanisms leads to various diseases, including cancer. Especially, given the importance of stem cells in early development, DNA repair deficiency in stem cells leads to various disabilities like developmental delay, premature aging, sensitivity to DNA damaging agents, degenerative diseases, etc. In this review, we have summarized the recent update about how DNA repair mechanisms are regulated in stem cells and their association with disease progression and pathogenesis.

    Original languageEnglish (US)
    Article number165444
    JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
    Issue number4
    StatePublished - Apr 1 2020


    • DNA damage and repair
    • Disease
    • Gene Therapy
    • Stem cells

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology


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