Abstract
This single institution cohort study of 132 AML patients investigated the clinical implications of co-mutations detected with a 42-gene NGS panel. In the intermediate-risk cytogenetic group, FLT3-ITD is an adverse prognostic indicator only in the presence of a DNMT3A co-mutation, regardless of NPM1 mutation status. In the absence of a concomitant DNMT3A mutation, there was no significant difference in overall survival between FLT3-ITD positive and FLT3-ITD negative patients. Furthermore, mutation analysis on post-induction specimens showed that residual FLT3-ITD and/or DNMT3A mutations were associated with a high frequency of therapy resistance or relapse in AML. While FLT3-ITD positive patients are currently considered high risk, incorporation of DNMT3A mutation status may be needed to refine prognostication and guide clinical management in AML. Multi-gene mutation testing is essential to provide novel insights related to diagnostic and prognostic information.
Original language | English (US) |
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Pages (from-to) | 1938-1948 |
Number of pages | 11 |
Journal | Leukemia and Lymphoma |
Volume | 59 |
Issue number | 8 |
DOIs | |
State | Published - Aug 3 2018 |
Keywords
- Myeloid leukemias and dysplasias
- cytogenetics
- molecular genetics
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research