Abstract
In vivo microdialysis techniques were used to examine whether endogenous excitatory amino acids exert a tonic facilitatory influence on striatal dopamine release. Local application of NMDA and non-NMDA antagonists at 10 μM was without an effect on basal dopamine release while 100 μM and 1 mM of these drugs significantly enhanced the release. Our findings do not support the idea that excitatory amino acids have a tonic excitatory effect on striatal dopamine release.
Original language | English (US) |
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Pages (from-to) | 329-330 |
Number of pages | 2 |
Journal | Brain research |
Volume | 544 |
Issue number | 2 |
DOIs | |
State | Published - Mar 29 1991 |
Externally published | Yes |
Keywords
- Dopamine
- Excitatory amino acid
- Microdialysis
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology