TY - JOUR
T1 - Do Racial Differences in Prostate Size Explain Higher Serum Prostate-Specific Antigen Concentrations Among Black Men?
AU - Mavropoulos, John C.
AU - Partin, Alan W.
AU - Amling, Christopher L.
AU - Terris, Martha K.
AU - Kane, Christopher J.
AU - Aronson, William J.
AU - Presti, Joseph C.
AU - Mangold, Leslie A.
AU - Freedland, Stephen J.
N1 - Funding Information:
This study was supported by National Institutes of Health (NIH) Specialized Programs of Research Excellence Grant P50CA58236 (A.W.P.), the Department of Veterans Affairs, the Georgia Cancer Coalition (M.K.T.), NIH R01CA100938 (W.J.A.), NIH Specialized Programs of Research Excellence Grant P50 CA92131-01A1 (W.J.A.), the Department of Defense Prostate Cancer Research Program (S.J.F.), and the American Urological Association Foundation/Astellas Rising Star in Urology Award (S.J.F.).
PY - 2007/6
Y1 - 2007/6
N2 - Objectives: To determine whether elevated serum prostate-specific antigen (PSA) values in black men are due, at least partially, to larger prostate size among black men. Methods: The study population consisted of two cohorts: (1) 1410 men undergoing radical prostatectomy between 1988 and 2005 at five equal-access medical centers comprising the Shared Equal Access Regional Cancer Hospital (SEARCH) Database; and (2) 9601 men undergoing radical prostatectomy between 1988 and 2004 at the Johns Hopkins Hospital. We evaluated the association between race and serum PSA value and prostate weight using multivariable linear regression while adjusting for demographic and clinicopathologic cancer characteristics. Results: In both cohorts, black men had higher serum PSA values (P ≤0.001). After adjusting for either demographic characteristics or demographic and cancer-specific characteristics, there were no significant associations between race and prostate size in either cohort. After adjusting for multiple demographic, clinical, and pathologic cancer-specific characteristics, black men had 15% higher serum PSA values relative to white men in both the SEARCH (P = 0.001) and Hopkins cohorts (P <0.001). Conclusions: In this study of patients undergoing radical prostatectomy in two very different practice settings, black men in both cohorts had higher serum PSA values relative to white men, despite adjustment for demographic and cancer-specific characteristics, including prostate weight. The lack of significant association between race and prostate size suggests that alternative reasons are needed to explain higher serum PSA values in black men.
AB - Objectives: To determine whether elevated serum prostate-specific antigen (PSA) values in black men are due, at least partially, to larger prostate size among black men. Methods: The study population consisted of two cohorts: (1) 1410 men undergoing radical prostatectomy between 1988 and 2005 at five equal-access medical centers comprising the Shared Equal Access Regional Cancer Hospital (SEARCH) Database; and (2) 9601 men undergoing radical prostatectomy between 1988 and 2004 at the Johns Hopkins Hospital. We evaluated the association between race and serum PSA value and prostate weight using multivariable linear regression while adjusting for demographic and clinicopathologic cancer characteristics. Results: In both cohorts, black men had higher serum PSA values (P ≤0.001). After adjusting for either demographic characteristics or demographic and cancer-specific characteristics, there were no significant associations between race and prostate size in either cohort. After adjusting for multiple demographic, clinical, and pathologic cancer-specific characteristics, black men had 15% higher serum PSA values relative to white men in both the SEARCH (P = 0.001) and Hopkins cohorts (P <0.001). Conclusions: In this study of patients undergoing radical prostatectomy in two very different practice settings, black men in both cohorts had higher serum PSA values relative to white men, despite adjustment for demographic and cancer-specific characteristics, including prostate weight. The lack of significant association between race and prostate size suggests that alternative reasons are needed to explain higher serum PSA values in black men.
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U2 - 10.1016/j.urology.2007.01.102
DO - 10.1016/j.urology.2007.01.102
M3 - Article
C2 - 17572202
AN - SCOPUS:34250010609
SN - 0090-4295
VL - 69
SP - 1138
EP - 1142
JO - Urology
JF - Urology
IS - 6
ER -