Abstract
The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 440-444 |
| Number of pages | 5 |
| Journal | Ocular Immunology and Inflammation |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 3 2016 |
Keywords
- Ankylosing spondylitis
- HLA-B27
- microbiome
- spondyloarthropathy
- uveitis
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology