The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets.
|Original language||English (US)|
|Number of pages||5|
|Journal||Ocular Immunology and Inflammation|
|State||Published - Jul 3 2016|
- Ankylosing spondylitis
ASJC Scopus subject areas
- Immunology and Allergy