Does the Microbiome Cause B27-related Acute Anterior Uveitis?

James T. Rosenbaum, Phoebe Lin, Mark Asquith

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalOcular Immunology and Inflammation
Issue number4
StatePublished - Jul 3 2016


  • Ankylosing spondylitis
  • HLA-B27
  • microbiome
  • spondyloarthropathy
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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