Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample

Jeremy R. Parr, Ann Le Couteur, Gillian Baird, Michael Rutter, Andrew Pickles, Eric Fombonne, Anthony J. Bailey, Simon Wallace, Kerstin Wittemeyer, Anthony Monaco, Gabrielle Barnby, Patrick Bolton, Janette Moore, Marianna Murin, Helen McConachie, Tom Berney, Zoe Docherty, Stephen Abbs, Caroline Ogilvie, Pamela WarburtonJanine Lamb, Jonathan Green, Bryan Bolton, Ros Packer, Demetrious Haracopos, Lennart Pedersen, Torben Isager, Karen Brondum-Nielsen, Bernadette Roge, Maïté Tauber, Carine Mantoulan, Fritz Poustka, Sven Bölte, Sabine Feineis-Matthews, Dorothea Rühl, Gabriele Schmötzer, Annemarie Poustka, Sabine M. Klauck, John Tsiantis, Katerina Papanikolaou, Elena Maestrini, Herman Van Engeland, Maretha De Jonge, Catherine Lord, Christina Corsello, Edwin Cook, Jeff Salt, Stephen Guter, Bennett Leventhal, Fred Volkmar, Kathleen Koenig

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself.

Original languageEnglish (US)
Pages (from-to)332-340
Number of pages9
JournalJournal of autism and developmental disorders
Issue number3
StatePublished - Mar 2011
Externally publishedYes


  • ASD
  • Concordance
  • Development
  • Genetics
  • Language
  • Regression

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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