Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques

Jodi L. Downs, Julie A. Mattison, Donald K. Ingram, Henryk F. Urbanski

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations


    Dietary caloric restriction (CR) slows aging, extends lifespan, and reduces the occurrence of age-related diseases in short-lived species. However, it is unclear whether CR can exert similar beneficial effects in long-lived species, like primates. Our objective was to determine if CR could attenuate purported age-related changes in the 24-h release of adrenal steroids. To this end, we examined 24-h plasma profiles of cortisol, and dehydroepiandrosterone sulfate (DHEAS) in young and old, male and female rhesus macaques (Macaca mulatta) subjected to either ad libitum (AL)-feeding or CR (70% of AL) for 2-4 years. Hormone profiles from young monkeys showed pronounced 24-h rhythms. Cortisol concentrations were higher in old males but not females, whereas DHEAS rhythms were dampened with age in both sexes. The cortisol rhythms of old CR males resembled those of young control males. However, CR failed to prevent age-related declines in DHEAS and further dampened DHEAS rhythms in both sexes. Apart from the partial attenuation of the age-related cortisol elevation in the old males, 24-h adrenal steroid rhythms did not benefit from late-onset CR.

    Original languageEnglish (US)
    Pages (from-to)1412-1422
    Number of pages11
    JournalNeurobiology of Aging
    Issue number9
    StatePublished - Sep 2008


    • Adrenal steroids
    • Aging
    • Caloric restriction
    • Circadian
    • Cortisol
    • DHEAS
    • Endocrine rhythms
    • Primate

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Aging
    • Clinical Neurology
    • Developmental Biology
    • Geriatrics and Gerontology


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