Effect of an Opiate Antagonist on Movement Disorders

John G. Nutt, Arnold J. Rosin, Toomas Eisler, Donald B. Calne, Thomas N. Chase

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Animal experiments suggest that opiate peptides might play a role in extrapyramidal function. This hypothesis was tested by administering the opiate antagonist, naltrexone, in doses sufficient to antagonize exogenous opiates, to patients with parkinsonism and Huntington's disease. No improvement in the clinical features of either disorder was noted.

Original languageEnglish (US)
Pages (from-to)810-811
Number of pages2
JournalArchives of Neurology
Issue number12
StatePublished - Dec 1978
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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