Effect of central adenosine on brainstem blood flow in fetal sheep

JM Bissonnette, AR Hohimer, SJ Knopp

Research output: Contribution to journalArticlepeer-review


The effect of the adenosine analogue R‐N6‐(phenylisopropyl)adenosine (R‐PIA) on blood flow to the medulla and pons was examined in unanaesthetized fetal sheep. Microspheres labelled with isotopes were used to determine blood flow before and after instillation of 0.2 or 0.5 microgram R‐PIA into the cerebrospinal fluid of the fourth ventricle. Blood flow to the medulla, which had a mean value (+/− S.E.M.) of 285 +/− 41 ml min‐1 (100 g)‐1 during the control period, was not changed by the central instillation of R‐PIA. Blood flow to the pons was also not affected. These data indicate that central adenosine, which depresses respiratory drive in fetal sheep, acts by mechanisms independent of removal of carbon dioxide from the brainstem.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalExperimental physiology
Issue number1
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)


Dive into the research topics of 'Effect of central adenosine on brainstem blood flow in fetal sheep'. Together they form a unique fingerprint.

Cite this