@article{85e2a4c9a2484a4fb56a4ff0571eb479,
title = "Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons",
abstract = "Background: We evaluated whether menstrual cycle phase influences the assessment of tubal patency by hysterosalpingography (HSG) in baboons. Methods: Retrospective analysis of baseline tubal patency studies and serum estradiol (E2) and progesterone (P4) values obtained from female baboons used as models for development of non-surgical permanent contraception in women. The main outcome measure was bilateral tubal patency (BTP) in relationship with estradiol level. Results: Female baboons (n = 110) underwent a single (n = 81), two (n = 26), or three (n = 3) HSG examinations. In 33/142 (23%) HSG examinations, one or both tubes showed functional occlusion (FO). The median E2 in studies with BTP (49 pg/mL) was significantly higher than in those studies with FO (32 pg/mL, P =.005). Among 18 animals with repeat examinations where serum E2 changed from <60 to ≥ 60 pg/mL, 13 results changed from FO to BTP (P =.0001). No sets showed a change from BTP to FO with an increase in estradiol. Conclusion: In baboons, functional occlusion of the fallopian tube is associated with low estradiol levels, supporting a role for estrogen-mediated relaxation of the utero-tubal junction.",
keywords = "baboon, estradiol, fallopian tubes, hysterosalpingography",
author = "Jensen, {Jeffrey T.} and Carol Hanna and Emily Mishler and Lim, {Jeong Y.} and Slayden, {Ov D.}",
note = "Funding Information: This research was supported by generous grants from the Bill & Melinda Gates Foundation (OPP1060424, OPP1084270, OPP1118762). Core facilities at ONPRC and SNPRC are supported by NIH Office of Research Infrastructure P51 RR000163 and P51 RR013986. Funding Information: Funding information This research was supported by generous grants from the Bill & Melinda Gates Foundation (OPP1060424, OPP1084270, OPP1118762). Core facilities at ONPRC and SNPRC are supported by NIH Office of Research Infrastructure P51 RR000163 and P51 RR013986. This research was supported by generous grants from the Bill & Melinda Gates Foundation (OPP1060424, OPP1084270, OPP1118762) and through the Southwest National Primate Center (SNPRC) Research Resource Request Pilot Project Program; VS1011 PC Pilot Program Award. The core facilities at ONPRC and SNPRC are supported by the NIH Office of Research Infrastructure P51 RR000163 and P51 RR013986. The authors wish to thank the clinical veterinary staff and animal care technicians of at SNPRC and ONPRC for their excellent animal care. Cook Medical Devices in Bloomington, IN provided the catheters used in this study. Funding Information: This research was supported by generous grants from the Bill & Melinda Gates Foundation (OPP1060424, OPP1084270, OPP1118762) and through the Southwest National Primate Center (SNPRC) Research Funding Information: Resource Request Pilot Project Program; VS1011 PC Pilot Program Award. The core facilities at ONPRC and SNPRC are supported by the NIH Office of Research Infrastructure P51 RR000163 and P51 RR013986. The authors wish to thank the clinical veterinary staff and animal care technicians of at SNPRC and ONPRC for their excellent animal care. Cook Medical Devices in Bloomington, IN provided the catheters used in this study. Publisher Copyright: {\textcopyright} 2017 The Authors. Journal of Medical Primatology Published by John Wiley & Sons Ltd",
year = "2018",
month = feb,
doi = "10.1111/jmp.12317",
language = "English (US)",
volume = "47",
pages = "40--45",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "1",
}