Effect of Obesity on Mortality in Pulmonary Hypertension—A Systematic Review and Meta-Analysis

Raju Reddy, Saminder Singh Kalra, Bashar Alzghoul, Akram Khan, Yazan Zayed

Research output: Contribution to journalReview articlepeer-review

Abstract

Obesity is reported to have a protective effect on mortality in pulmonary hypertension (PH), a phenomenon known as obesity paradox. However, the data are conflicting, with some studies showing decreased mortality while other studies found no effect of obesity on mortality. Therefore, we performed a systematic review and meta-analysis to examine whether there is an association between obesity and mortality in PH. Only patients with PH diagnosed by right heart catheterization were included. We also performed a sub-group analysis of subjects with pre-capillary PH only. A total of six studies met the inclusion criteria, with a sample size of 13,987 patients. Obese subjects had lower mortality compared to non-obese subjects in the combined pre- and post-capillary PH group (hazard ratio 0.79, 95% CI 0.66–0.95, p = 0.01). While obesity was associated with reduction in mortality in the pre-capillary PH group (hazard ratio 0.77, 95% CI 0.60 to 0.98, p = 0.03), this was not uniform across all studies.

Original languageEnglish (US)
Article number419
JournalJournal of Cardiovascular Development and Disease
Volume10
Issue number10
DOIs
StatePublished - Oct 2023

Keywords

  • body mass index
  • mortality
  • obesity
  • pulmonary hypertension

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)

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