TY - JOUR
T1 - Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori
AU - Laine, Loren
AU - Estrada, Roque
AU - Trujillo, Maria
AU - Knigge, Kandice
AU - Fennerty, M. Brian
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1998/10
Y1 - 1998/10
N2 - Background: Proton-pump inhibitor therapy may cause false-negative results on Helicobacter pylori diagnostic testing. Objective: To determine the frequency and duration of conversion of urea breath test results from positive to negative in patients given a proton-pump inhibitor. Setting: Two urban university gastroenterology clinics. Patients: Patients infected with H. pylori who had positive results on urea breath tests. Intervention: Lansoprazole, 30 mg/d for 28 days. Measurements: The urea breath test was repeated at 28 days. If the results were negative, testing was repeated 3, 7, 14, and 28 days after completion of therapy until the results reverted to positive. Results: 31 (33%) of 93 patients in whom H. pylori was not eradicated had a negative breath test result while receiving lansoprazole. The proportions of patients whose breath test results were positive after completion of lansoprazole therapy were 91% (95% CI, 83% to 96%) at 3 days, 97% (Cl, 90% to 99%) at 7 days, and 100% (Cl, 96% to 100%) at 14 days. Conclusion: Patients should not receive proton-pump inhibitors for 2 weeks before receiving the urea breath test for H. pylori infection.
AB - Background: Proton-pump inhibitor therapy may cause false-negative results on Helicobacter pylori diagnostic testing. Objective: To determine the frequency and duration of conversion of urea breath test results from positive to negative in patients given a proton-pump inhibitor. Setting: Two urban university gastroenterology clinics. Patients: Patients infected with H. pylori who had positive results on urea breath tests. Intervention: Lansoprazole, 30 mg/d for 28 days. Measurements: The urea breath test was repeated at 28 days. If the results were negative, testing was repeated 3, 7, 14, and 28 days after completion of therapy until the results reverted to positive. Results: 31 (33%) of 93 patients in whom H. pylori was not eradicated had a negative breath test result while receiving lansoprazole. The proportions of patients whose breath test results were positive after completion of lansoprazole therapy were 91% (95% CI, 83% to 96%) at 3 days, 97% (Cl, 90% to 99%) at 7 days, and 100% (Cl, 96% to 100%) at 14 days. Conclusion: Patients should not receive proton-pump inhibitors for 2 weeks before receiving the urea breath test for H. pylori infection.
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U2 - 10.7326/0003-4819-129-7-199810010-00007
DO - 10.7326/0003-4819-129-7-199810010-00007
M3 - Article
C2 - 9758575
AN - SCOPUS:0032189688
SN - 0003-4819
VL - 129
SP - 547
EP - 550
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 7
ER -