Effect of Sodium Intake on Gentamicin Nephrotoxicity in the Rat

William M. Bennett, Michael N. Hartnett, David Gilbert, Donald Houghton, George A. Porter

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Gentamicin nephrotoxicity was examined in rats on normal, high, and low sodium diets. Low sodium diet markedly potentiated nephrotoxic effects of the drug as evidenced by animal mortality, renal failure, pathological changes, and increased renal cortical concentration of the drug. High sodium intake reduced the cortical concentration of gentamicin but renal function and ultrastructure were similar to normally fed rats given in the same dose.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number4
StatePublished - Apr 1976

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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