Effects of imipramine on the sleep-dream cycle: An EEG study in boys

Edward R. Ritvo, Edward M. Ornitz, Steven La Franchi, Richard D. Walter

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The effect of imipramine on the sleep cycle in seven boys, aged 9-11, was studied by a single blind technique recording EEG and EOM. It was demonstrated that imipramine influences the sleep-dream cycle in the following manner: (1) the percentage of time spent in REM state sleep was decreased; (2) the percentage of time spent in Stage 2 sleep was increased; (3) a longer latency from the onset of sleep to the first REM epoch was produced. No difference was observed between the amounts of time spent in combined Stages 3-4 sleep or in the over-all length of time spent asleep in the laboratory.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalElectroencephalography and Clinical Neurophysiology
Issue number5
StatePublished - May 1967
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


Dive into the research topics of 'Effects of imipramine on the sleep-dream cycle: An EEG study in boys'. Together they form a unique fingerprint.

Cite this