Effects of melatonin and propranolol on sleep of the rat

Wallace B. Mendelson; J. Christian Gillin; Susan D. Dawson; Alfred J. Lewy; Richard Jed Wyatt

doi:10.1016/0006-8993(80)90793-3

Effects of melatonin and propranolol on sleep of the rat

Wallace B. Mendelson, J. Christian Gillin, Susan D. Dawson, Alfred J. Lewy, Richard Jed Wyatt

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

Original language	English (US)
Pages (from-to)	240-244
Number of pages	5
Journal	Brain research
Volume	201
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)90793-3
State	Published - Nov 10 1980
Externally published	Yes

Keywords

REM sleep
l-propranolol
melatonin
sleep

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(80)90793-3

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abstract = "Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.",

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AU - Mendelson, Wallace B.

AU - Gillin, J. Christian

AU - Dawson, Susan D.

AU - Lewy, Alfred J.

AU - Wyatt, Richard Jed

PY - 1980/11/10

Y1 - 1980/11/10

N2 - Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

AB - Melatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.

KW - REM sleep

KW - l-propranolol

KW - melatonin

KW - sleep

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Effects of melatonin and propranolol on sleep of the rat

Abstract

Keywords

ASJC Scopus subject areas

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