Effects of Positive End‐Expiratory Pressure on Renal Function

P. ‐O Järnberg, E. Dominguez de Villota, J. Eklund, P. ‐O Granberg

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The effects were studied of positive end‐expiratory pressure (PEEP) on renal function in eight patients with acute respiratory failure, requiring mechanical ventilation. On application of PEEP+ 10 cmH2O, central venous pressure increased, systolic blood pressure decreased, urine flow and PAH‐clearance were reduced, while inulin clearance remained stable. There was a marked increase in fractional sodium reabsorption and a concurrent decrease in fractional osmolal excretion. Fractional free‐water clearance and the ratio Uosm/Posm did not change.

Original languageEnglish (US)
Pages (from-to)508-514
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Issue number5
StatePublished - Oct 1978
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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