The effects were studied of positive end‐expiratory pressure (PEEP) on renal function in eight patients with acute respiratory failure, requiring mechanical ventilation. On application of PEEP+ 10 cmH2O, central venous pressure increased, systolic blood pressure decreased, urine flow and PAH‐clearance were reduced, while inulin clearance remained stable. There was a marked increase in fractional sodium reabsorption and a concurrent decrease in fractional osmolal excretion. Fractional free‐water clearance and the ratio Uosm/Posm did not change.
|Number of pages
|Acta Anaesthesiologica Scandinavica
|Published - Oct 1978
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine