@article{81e2e060fbd4482983691f443119843e,
title = "Elevated umbilical cord blood leukocyte cyclic adenosine monophosphate-phosphodiesterase activity in children with atopic parents",
abstract = "We found cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity to be significantly elevated in the umbilical cord blood mononuclear leukocytes of forty-two children with one atopic parent (3.2 ± 0.3) and in eighteen children with two atopic parents (4.2 ± 0.7) as compared to twenty-two children with two nonatopic parents (1.9 ± 0.2) (p < 0.005). Among those newborns with one atopic parent, mean PDE activities were significantly elevated in cord blood cells regardless of whether only the father was atopic, thus eliminating the possibility of transplacental enzyme passage. Follow-up evaluations of twenty-four children, age 6 months or older, suggest that infants with elevated PDE activity at birth have an increased likelihood of developing dermatitis and/or “atopic features.” Further long-term studies will determine the predictive value of newborn mononuclear leukocyte PDE activity.",
author = "Heskel, {Neil S.} and Chan, {Sai C.} and Thiel, {Marcella L.} and Stevens, {Seth R.} and Casperson, {L. S.} and Hanifin, {Jon M.}",
note = "Funding Information: From the Department of Dermatology, The Oregon Health Sciences University. Supported in part by a grant from The National Institutes of Health (5 ROI AI 18615) and from the Bramble Medical Research Foun-dation. Presented in part to the Western Society for Pediatric Research, Car-mel, CA, February, 1983, and to The Society For Investigative Dermatology; Washington, DC, April, 1983. Accepted for publication Feb. 9, 1984. Reprint requests to: Dr. Jon M. Hanifin, Department of Dermatol-ogy, The Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd.:, Port'land, OR 97201. *Johnson ML: Prevalence of dermatologic disease among persons 1-74 years of age: United States. Ad~,ance data from vital and health statistics of the National Center for Health Statistics, No. 4, Jan. 26, 1977.",
year = "1984",
doi = "10.1016/S0190-9622(84)70184-8",
language = "English (US)",
volume = "11",
pages = "422--426",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "3",
}