Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy

Morgan Hakki; Janet F. Staab; Kieren A. Marr

doi:10.1128/AAC.00148-06

Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy

Morgan Hakki, Janet F. Staab, Kieren A. Marr

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.

Original language	English (US)
Pages (from-to)	2522-2524
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00148-06
State	Published - Jul 2006
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy",

abstract = "Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.",

author = "Morgan Hakki and Staab, {Janet F.} and Marr, {Kieren A.}",

year = "2006",

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AU - Hakki, Morgan

AU - Staab, Janet F.

AU - Marr, Kieren A.

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N2 - Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.

AB - Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.

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Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy

Abstract

ASJC Scopus subject areas

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