Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

Carlos F. Aylwin, Carlos A. Toro, Elizabeth Shirtcliff, Alejandro Lomniczi

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.

Original languageEnglish (US)
Pages (from-to)54-79
Number of pages26
JournalJournal of Research on Adolescence
Issue number1
StatePublished - Mar 2019

ASJC Scopus subject areas

  • Cultural Studies
  • Developmental and Educational Psychology
  • Social Sciences (miscellaneous)
  • Behavioral Neuroscience


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