End-stage renal disease due to polyomavirus in a cardiac transplant patient

Supriya Maddirala, Jan V. Pitha, Benjamin D. Cowley, Lukas Haragsim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: A 51-year-old male orthotopic cardiac transplant recipient experienced a prolonged rejection episode immediately after transplantation. Three years and 5 months after transplantation, he presented with lower extremity swelling; at this presentation, the patient's serum creatinine level was 345 μmol/l (3.9 mg/dl), his urinalysis was trace positive for both protein and blood, the urinary sediment had no casts and his 24-hour urine collection showed 750 mg protein. The patient's renal function deteriorated over the next month, with his serum creatinine level reaching a peak of 530 μmol/l (6 mg/dl). He died 4 years and 3 months after transplantation as a result of an arrhythmia. Investigations: Physical examination, urine and blood analyses, ultrasound-guided renal biopsy and autopsy. Diagnosis: Polyomavirus-associated nephropathy with the development of end-stage renal disease. Management: Adjustment of immunosuppressive therapy and initiation of hemodialysis.

Original languageEnglish (US)
Pages (from-to)393-396
Number of pages4
JournalNature Clinical Practice Nephrology
Issue number7
StatePublished - Jul 2007
Externally publishedYes


  • Cardiac transplantation
  • End-stage renal disease
  • Immunosuppression
  • Polyomavirus-associated nephropathy

ASJC Scopus subject areas

  • Nephrology


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