@article{a49c99dae6484b3093df2401e6910fa8,
title = "Endocardially Derived Macrophages Are Essential for Valvular Remodeling",
abstract = "Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.",
keywords = "cardiac tissue macrophage, cardiogenesis, congenital heart disease, hematopoiesis, hemogenic endocardium, multipotent cardiac progenitor cells, tissue macrophages, valve disease, valve remodeling, valvulogenesis",
author = "Ayako Shigeta and Vincent Huang and Jonathan Zuo and Rana Besada and Yasuhiro Nakashima and Yan Lu and Yichen Ding and Matteo Pellegrini and Kulkarni, {Rajan P.} and Tzung Hsiai and Arjun Deb and Bin Zhou and Haruko Nakano and Atsushi Nakano",
note = "Funding Information: The authors thank Drs. Alvaro Sagasti, Karen Lyons, and Hanna K.A. Mikkola (UCLA) for the critical reading of the manuscript and Dr. Hajime Yokota for the assistance in bioinformatics analyses. Dr. Kouki Morizono (UCLA) advised on the macrophage phagocytosis assay. Technical support was provided by the BSCRC flow cytometry core, the BSCRC sequencing core, and the UCLA histology core. This work was supported by NIH , United States ( HL127427 to A.N., HL129178 and HL137241 to A.D., and HL111437 and HL129727 to T.H.). The authors were supported by fellowships from the Japanese Respiratory Foundation-Pfizer (A.S.), the Howard Hughes Medical Institute (V.H.), the UCLA Program for Excellence in Education and Research in the Sciences (PEERS) (R.B.), the Japanese Circulation Society (Y.N.), and the Uehara Memorial Foundation (Y.N.). Funding Information: The authors thank Drs. Alvaro Sagasti, Karen Lyons, and Hanna K.A. Mikkola (UCLA) for the critical reading of the manuscript and Dr. Hajime Yokota for the assistance in bioinformatics analyses. Dr. Kouki Morizono (UCLA) advised on the macrophage phagocytosis assay. Technical support was provided by the BSCRC flow cytometry core, the BSCRC sequencing core, and the UCLA histology core. This work was supported by NIH, United States (HL127427 to A.N., HL129178 and HL137241 to A.D., and HL111437 and HL129727 to T.H.). The authors were supported by fellowships from the Japanese Respiratory Foundation-Pfizer (A.S.), the Howard Hughes Medical Institute (V.H.), the UCLA Program for Excellence in Education and Research in the Sciences (PEERS) (R.B.), the Japanese Circulation Society (Y.N.), and the Uehara Memorial Foundation (Y.N.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = mar,
day = "11",
doi = "10.1016/j.devcel.2019.01.021",
language = "English (US)",
volume = "48",
pages = "617--630.e3",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "5",
}