Enhanced preganglionic sympathetic nerve responses in spontaneously hypertensive rats

S. F. Morrison, D. Whitehorn

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Sympathetic nerve responses to posterior hypothalamic stimulation were recorded from the preceliac splanchnic nerve in spontaneously hypertensive rats (SHR) and normotensive, Wistar-Kyoto rats (WKY) following interruption of the baroreceptor reflex. Responses to identical stimulation were then recorded following ganglionic blockade with hexamethonium. The enhanced preganglionic sympathetic nerve responses measured in SHR indicate that the sympathetic hyperresponsiveness in this hypertensive strain occurs, at least in part, at a site within the central nervous system.

Original languageEnglish (US)
Pages (from-to)152-155
Number of pages4
JournalBrain research
Issue number1
StatePublished - Mar 26 1984
Externally publishedYes


  • ganglionic blockade
  • posterior hypothalamic stimulation
  • preceliac splanchnic nerve
  • spontaneously hypertensive rat

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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