Abstract
Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.
Original language | English (US) |
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Pages (from-to) | 229-233 |
Number of pages | 5 |
Journal | Virology |
Volume | 374 |
Issue number | 2 |
DOIs | |
State | Published - May 10 2008 |
Externally published | Yes |
Keywords
- Env sequence length
- HIV-1
- N-linked glycosylation sites
- Primary infection
- Transmission
ASJC Scopus subject areas
- Virology