Enzymatic synthesis of dipeptides in ionic liquids

Sanjay V. Malhotra, Chengdong Zhang, Hao Wang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF 6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for bio- catalysis.

Original languageEnglish (US)
Pages (from-to)168-171
Number of pages4
JournalLetters in Organic Chemistry
Issue number2
StatePublished - Mar 2010
Externally publishedYes


  • Dipeptides
  • Enzymatic synthesis
  • Ionic liquid
  • Protease

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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