Enzymatic synthesis of dipeptides in ionic liquids

Sanjay V. Malhotra; Chengdong Zhang; Hao Wang

doi:10.2174/157017810790796318

Enzymatic synthesis of dipeptides in ionic liquids

Sanjay V. Malhotra, Chengdong Zhang, Hao Wang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF ₆, BMIM.BF₄ and EtPy.BF₄ have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for bio- catalysis.

Original language	English (US)
Pages (from-to)	168-171
Number of pages	4
Journal	Letters in Organic Chemistry
Volume	7
Issue number	2
DOIs	https://doi.org/10.2174/157017810790796318
State	Published - Mar 2010
Externally published	Yes

Keywords

Dipeptides
Enzymatic synthesis
Ionic liquid
Protease

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.2174/157017810790796318

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title = "Enzymatic synthesis of dipeptides in ionic liquids",

abstract = "Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF 6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for bio- catalysis.",

keywords = "Dipeptides, Enzymatic synthesis, Ionic liquid, Protease",

author = "Malhotra, {Sanjay V.} and Chengdong Zhang and Hao Wang",

year = "2010",

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doi = "10.2174/157017810790796318",

language = "English (US)",

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T1 - Enzymatic synthesis of dipeptides in ionic liquids

AU - Malhotra, Sanjay V.

AU - Zhang, Chengdong

AU - Wang, Hao

PY - 2010/3

Y1 - 2010/3

N2 - Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF 6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for bio- catalysis.

AB - Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF 6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for bio- catalysis.

KW - Dipeptides

KW - Enzymatic synthesis

KW - Ionic liquid

KW - Protease

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EP - 171

JO - Letters in Organic Chemistry

JF - Letters in Organic Chemistry

IS - 2

ER -

Enzymatic synthesis of dipeptides in ionic liquids

Abstract

Keywords

ASJC Scopus subject areas

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