TY - JOUR
T1 - Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women
AU - Shikary, Tasneem
AU - Bernstein, David I.
AU - Jin, Yan
AU - Zimet, Gregory D.
AU - Rosenthal, Susan L.
AU - Kahn, Jessica A.
N1 - Funding Information:
Dr. Zimet is a co-Principal Investigator on an investigator initiated grant funded by Merck and serves as a research consultant/collaborator on a Merck-sponsored research project.
PY - 2009/10
Y1 - 2009/10
N2 - Background: Two HPV vaccines prevent infection with HPV-16 and HPV-18, high-risk (cancer-associated) HPV types which together cause approximately 70% of cervical cancers; one vaccine also prevents HPV-6 and HPV-11, which together cause approximately 90% of anogenital warts. Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. Objectives: To examine HPV epidemiology in a diverse sample of sexually experienced women, and to determine factors associated with high-risk HPV and vaccine-type HPV (HPV-6, HPV-11, HPV-16 and HPV-18). Study design: Cross-sectional study of 13-26-year-old women (N = 409) who completed a questionnaire and provided a cervicovaginal swab. Swabs were genotyped for HPV using PCR amplification. Logistic regression models were used to determine whether participant characteristics, knowledge, and behaviors were associated with high-risk and vaccine-type HPV. Results: Most women (68.4%) were positive for ≥1 HPV type, 59.5% were positive for ≥1 high-risk type, 33.1% were positive for ≥1 vaccine-type HPV, and 3.5% were positive for both HPV-16 and HPV-18: none was positive for all four vaccine types. In adjusted logistic regression models, Black race (OR 2.03, 95% CI 1.21-3.41) and lifetime number of male sexual partners (OR 4.79, 95% CI 2.04-11.23 for ≥10 partner vs. ≤1 partner) were independently associated with high-risk HPV infection. Conclusions: HPV prevalence was very high in this sample of sexually active young women, but <5% were positive for both HPV-16 and HPV-18, suggesting that vaccination could be beneficial for many individual women who are sexually experienced.
AB - Background: Two HPV vaccines prevent infection with HPV-16 and HPV-18, high-risk (cancer-associated) HPV types which together cause approximately 70% of cervical cancers; one vaccine also prevents HPV-6 and HPV-11, which together cause approximately 90% of anogenital warts. Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. Objectives: To examine HPV epidemiology in a diverse sample of sexually experienced women, and to determine factors associated with high-risk HPV and vaccine-type HPV (HPV-6, HPV-11, HPV-16 and HPV-18). Study design: Cross-sectional study of 13-26-year-old women (N = 409) who completed a questionnaire and provided a cervicovaginal swab. Swabs were genotyped for HPV using PCR amplification. Logistic regression models were used to determine whether participant characteristics, knowledge, and behaviors were associated with high-risk and vaccine-type HPV. Results: Most women (68.4%) were positive for ≥1 HPV type, 59.5% were positive for ≥1 high-risk type, 33.1% were positive for ≥1 vaccine-type HPV, and 3.5% were positive for both HPV-16 and HPV-18: none was positive for all four vaccine types. In adjusted logistic regression models, Black race (OR 2.03, 95% CI 1.21-3.41) and lifetime number of male sexual partners (OR 4.79, 95% CI 2.04-11.23 for ≥10 partner vs. ≤1 partner) were independently associated with high-risk HPV infection. Conclusions: HPV prevalence was very high in this sample of sexually active young women, but <5% were positive for both HPV-16 and HPV-18, suggesting that vaccination could be beneficial for many individual women who are sexually experienced.
KW - Cervical cancer
KW - Epidemiology
KW - Human papillomavirus
KW - Sexually transmitted infection
KW - Vaccination
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U2 - 10.1016/j.jcv.2009.07.006
DO - 10.1016/j.jcv.2009.07.006
M3 - Article
C2 - 19665924
AN - SCOPUS:69449085856
SN - 1386-6532
VL - 46
SP - 107
EP - 111
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
IS - 2
ER -