Abstract
Over the past decade, medicine has witnessed an explosion of new insights into the genomic events important for determining a woman’s susceptibility to ovarian cancer. Many of these insights also play a key role in determining clinical ovarian cancer outcomes. This chapter reviews our rapidly evolving understanding of these events. It places particular emphasis on those insights, such as our understanding of inherited syndromes of breast and ovarian cancer, that have dramatically expanded options for ovarian cancer prevention and treatment.
Original language | English (US) |
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Title of host publication | Genomic and Precision Medicine |
Subtitle of host publication | Oncology, Third Edition |
Publisher | Elsevier |
Pages | 173-190 |
Number of pages | 18 |
ISBN (Electronic) | 9780128006849 |
ISBN (Print) | 9780128006535 |
DOIs | |
State | Published - Jan 1 2022 |
Keywords
- BRCA1/2
- Epithelial ovarian cancer
- PARP inhibitors
- angiogenesis
- homologous recombination deficiency
- immune response
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)