Estrogen modulation of G-protein-coupled receptors

Martin J. Kelly, Edward J. Wagner

Research output: Contribution to journalReview articlepeer-review

193 Scopus citations


Estrogen exerts long-term effects in almost every cell through regulation of gene transcription. However, it has been known for some time that estrogen can rapidly alter neuronal firing within seconds, indicating that some cellular effects of estrogen could occur via non-genomic mechanisms. G-protein-coupled receptors (GPCRs) are the largest class of membrane-bound receptors, and it appears that many of the rapid effects mediated by estrogen could involve changes in GPCR-effector system coupling in excitable cells within the reproductive axis.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number9
StatePublished - Nov 1 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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