TY - CHAP
T1 - Estrogen Signaling in the Hypothalamus
AU - Kelly, Martin J.
AU - Qiu, Jian
AU - Rønnekleiv, Oline K.
N1 - Funding Information:
We thank Drs. Charles Roselli and Robert Shapiro and Ms. Anna Malyala for their thoughtful comments on this manuscript and Ms. Martha A. Bosch for skilled assistance with the illustrations and manuscript preparation. The work from the authors' laboratories was supported by Public Health Service grants: DA 05158 and NS 38809, NS 43330, NS 35944 and the Office of Research on Women's Health.
PY - 2005
Y1 - 2005
N2 - Estrogen has multifaceted effects on the hypothalamus that regulate a number of homeostatic functions including reproduction, temperature, energy balance, stress, and motivated behaviors. Estrogen targets all of the major hypothalamic neuroendocrine and autonomic cellular groups to activate multiple signaling pathways. Originally it was thought that all of these actions of estrogen could be ascribed to its binding to its "classical" intracellular receptor and to alterations in gene transcription. However, we now know that this steroid hormone activates multiple signaling pathways to affect neuronal excitability and gene transcription. Although the "classical" genomic signaling pathway has been recognized for almost half a century, until recently little attention has been paid to the rapid membrane-initiated signaling by estrogen in neurons. It has been known since the 1970s that estrogen can rapidly alter neuronal firing within seconds, indicating that some cellular effects of estrogen could occur via rapid, nontranscriptional mechanisms. Therefore, this chapter reviews the current status of estrogen signaling in the hypothalamus via membrane-initiated and nuclear-mediated events that affect the excitability of hypothalamic neurons and, ultimately, neuroendocrine and autonomic functions.
AB - Estrogen has multifaceted effects on the hypothalamus that regulate a number of homeostatic functions including reproduction, temperature, energy balance, stress, and motivated behaviors. Estrogen targets all of the major hypothalamic neuroendocrine and autonomic cellular groups to activate multiple signaling pathways. Originally it was thought that all of these actions of estrogen could be ascribed to its binding to its "classical" intracellular receptor and to alterations in gene transcription. However, we now know that this steroid hormone activates multiple signaling pathways to affect neuronal excitability and gene transcription. Although the "classical" genomic signaling pathway has been recognized for almost half a century, until recently little attention has been paid to the rapid membrane-initiated signaling by estrogen in neurons. It has been known since the 1970s that estrogen can rapidly alter neuronal firing within seconds, indicating that some cellular effects of estrogen could occur via rapid, nontranscriptional mechanisms. Therefore, this chapter reviews the current status of estrogen signaling in the hypothalamus via membrane-initiated and nuclear-mediated events that affect the excitability of hypothalamic neurons and, ultimately, neuroendocrine and autonomic functions.
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U2 - 10.1016/S0083-6729(05)71005-0
DO - 10.1016/S0083-6729(05)71005-0
M3 - Chapter
C2 - 16112267
AN - SCOPUS:27744560075
SN - 0127098712
SN - 9780127098715
T3 - Vitamins and Hormones
SP - 123
EP - 145
BT - Vitamins and Hormones
A2 - Litwack, Gerald
ER -