Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal.

L. Donald Keith; John C. Crabbe; Linda M. Robertson; Emmett R. Young

doi:10.1016/0024-3205(83)90673-2

Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal.

L. Donald Keith, John C. Crabbe, Linda M. Robertson, Emmett R. Young

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of β-endorphin-IR and α-MSH-IR. Differences in the pattern of ACTH-IR and α-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.

Original language	English (US)
Pages (from-to)	1889-1897
Number of pages	9
Journal	Life Sciences
Volume	33
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(83)90673-2
State	Published - Nov 7 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal.",

abstract = "The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of β-endorphin-IR and α-MSH-IR. Differences in the pattern of ACTH-IR and α-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.",

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AU - Keith, L. Donald

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PY - 1983/11/7

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AB - The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of β-endorphin-IR and α-MSH-IR. Differences in the pattern of ACTH-IR and α-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.

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Ethanol dependence and the pituitary adrenal axis in mice II. Temporal analysis of dependence and withdrawal.

Abstract

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