Evaluation of a time-resolved stress detection method to determine tissue optical properties

Helene Vijverberg, Sharon L. Thomsen, Steven L. Jacques, Alexander A. Oraevsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A new method to determine optical properties of biological tissue, time-resolved stress detection (TRSD), was tested on albino rat skin, heated in vitro. The TRSD method is based on the detection of pressure waves that are generated by short laser pulses. The pressure waves carry information about the optical properties (absorption and effective attenuation coefficients) of the medium. The evaluation was done in a systematic way by comparing the results of the TRSD method with results obtained using an integrating sphere. Measurements for both methods were performed on the same skin samples to minimize biological variations. The TRSD method proved to be reasonably successful to determine optical properties of tissue for the used wavelength of 355 nm: (1) The effective attenuation coefficients of both methods agreed very well; (2) The TRSD method gave absorption coefficients of a factor 2 + 0.5 times higher than the integrating sphere method; and (3) The reduced scattering coefficients were sensitive to error.

Original languageEnglish (US)
Title of host publicationLaser Interaction with Hard and Soft Tissue II
EditorsThomas H. Meier, Hans Joerg Albrecht, Martin J. C. van Gemert, Rudolf W. Steiner, Lars Othar Svaasand, Guy P. Delacretaz
Number of pages5
ISBN (Electronic)9780819416568
StatePublished - Jan 18 1995
Externally publishedYes
EventLaser Interaction with Hard and Soft Tissue II 1994 - Lille, France
Duration: Sep 6 1994Sep 10 1994

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


OtherLaser Interaction with Hard and Soft Tissue II 1994

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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