Evaluation of adverse effects of vaccines: The case-control approach

Liam Smeeth, Laura C. Rodrigues, Andrew J. Hall, Eric Fombonne, Peter G. Smith

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpretation of case-control studies to evaluate vaccine adverse effects. Potential biases (and how to minimise such biases) in the selection of cases and assessment of vaccine exposure and the potential for confounding are discussed. Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered.

Original languageEnglish (US)
Pages (from-to)2611-2617
Number of pages7
Issue number19-20
StatePublished - Jun 7 2002
Externally publishedYes


  • Adverse effects
  • Case-control
  • Vaccines

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


Dive into the research topics of 'Evaluation of adverse effects of vaccines: The case-control approach'. Together they form a unique fingerprint.

Cite this