@article{a49128b1aa7d43b19d3fe618bd3df94f,
title = "Evaluation of pediatric epigenetic clocks across multiple tissues",
abstract = "Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.",
keywords = "DNA methylation, Early childhood chronological age, Epigenetic clock, Gestational age",
author = "{on behalf of program collaborators for Environmental influences on Child Health Outcomes} and Fang Fang and Linran Zhou and Wei Perng and Marsit, {Carmen J.} and Knight, {Anna K.} and Andres Cardenas and Aung, {Max T.} and Hivert, {Marie France} and Aris, {Izzuddin M.} and Goodrich, {Jaclyn M.} and Smith, {Alicia K.} and Abigail Gaylord and Fry, {Rebecca C.} and Emily Oken and George O{\textquoteright}Connor and Ruden, {Douglas M.} and Leonardo Trasande and Herbstman, {Julie B.} and Camargo, {Carlos A.} and Bush, {Nicole R.} and Dunlop, {Anne L.} and Dabelea, {Dana M.} and Karagas, {Margaret R.} and Breton, {Carrie V.} and Carole Ober and Everson, {Todd M.} and Page, {Grier P.} and Christine Ladd-Acosta and Smith, {P. B.} and Newby, {L. K.} and Jacobson, {L. P.} and Catellier, {D. J.} and R. Gershon and D. Cella and Laham, {F. R.} and Mansbach, {J. M.} and S. Wu and Spergel, {J. M.} and Celed{\'o}n, {J. C.} and Puls, {H. T.} and Teach, {S. J.} and Porter, {S. C.} and Waynik, {I. Y.} and Iyer, {S. S.} and Samuels-Kalow, {M. E.} and A. D.Thompson and Stevenson, {M. D.} and Bauer, {C. S.} and Inhofe, {N. R.} and C. McEvoy",
note = "Publisher Copyright: {\textcopyright} 2023, BioMed Central Ltd., part of Springer Nature.",
year = "2023",
month = dec,
doi = "10.1186/s13148-023-01552-3",
language = "English (US)",
volume = "15",
journal = "Clinical epigenetics",
issn = "1868-7075",
publisher = "Springer Verlag",
number = "1",
}