TY - JOUR
T1 - Evaluation of reliability, validity, and responsiveness of the CDASI and the CAT-BM
AU - Goreshi, Renato
AU - Okawa, Joyce
AU - Rose, Matt
AU - Feng, Rui
AU - Lee, Lela A.
AU - Hansen, Christopher B.
AU - Bangert, Carolyn A.
AU - Connolly, M. Kari
AU - Davis, Mark D.
AU - Callen, Jeff P.
AU - Fett, Nicole M.
AU - Fakharzadeh, Steven S.
AU - Clarke, Jennie T.
AU - Werth, Victoria P.
N1 - Funding Information:
This material is based on work supported by Celgene Corporation, the Department of Veterans Affairs Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development, and by the National Institutes of Health (NIH K24-AR 02207) (VPW).
PY - 2012/4
Y1 - 2012/4
N2 - To properly evaluate therapies for cutaneous dermatomyositis (DM), it is essential to administer an outcome instrument that is reliable, valid, and responsive to clinical change, particularly when measuring disease activity. The purpose of this study was to compare two skin severity DM outcome measures, the Cutaneous Disease and Activity Severity Index (CDASI) and the Cutaneous Assessment Tool-Binary Method (CAT-BM), with the Physician Global Assessment (PGA) as the "gold standard". Ten dermatologists evaluated 14 patients with DM using the CDASI, CAT-BM, and PGA scales. Inter- and intra-rater reliability, validity, responsiveness, and completion time were compared for each outcome instrument. Responsiveness was assessed from a different study population, where one physician evaluated 35 patients with 110 visits. The CDASI was found to have a higher inter- and intra-rater reliability. Regarding construct validity, both the CDASI and the CAT-BM were significant predictors of the PGA scales. The CDASI had the best responsiveness among the three outcome instruments examined. The CDASI had a statistically longer completion time than the CAT-BM by about 1.5 minutes. The small patient population may limit the external validity of the findings observed. The CDASI is a better clinical tool to assess skin severity in DM.
AB - To properly evaluate therapies for cutaneous dermatomyositis (DM), it is essential to administer an outcome instrument that is reliable, valid, and responsive to clinical change, particularly when measuring disease activity. The purpose of this study was to compare two skin severity DM outcome measures, the Cutaneous Disease and Activity Severity Index (CDASI) and the Cutaneous Assessment Tool-Binary Method (CAT-BM), with the Physician Global Assessment (PGA) as the "gold standard". Ten dermatologists evaluated 14 patients with DM using the CDASI, CAT-BM, and PGA scales. Inter- and intra-rater reliability, validity, responsiveness, and completion time were compared for each outcome instrument. Responsiveness was assessed from a different study population, where one physician evaluated 35 patients with 110 visits. The CDASI was found to have a higher inter- and intra-rater reliability. Regarding construct validity, both the CDASI and the CAT-BM were significant predictors of the PGA scales. The CDASI had the best responsiveness among the three outcome instruments examined. The CDASI had a statistically longer completion time than the CAT-BM by about 1.5 minutes. The small patient population may limit the external validity of the findings observed. The CDASI is a better clinical tool to assess skin severity in DM.
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U2 - 10.1038/jid.2011.440
DO - 10.1038/jid.2011.440
M3 - Article
C2 - 22217740
AN - SCOPUS:84858297473
SN - 0022-202X
VL - 132
SP - 1117
EP - 1124
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 4
ER -