TY - JOUR
T1 - Evaluation of trabecular mechanical and microstructural properties in human calcaneal bone of advanced age using mechanical testing, μCT, and DXA
AU - Mittra, Erik
AU - Rubin, Clinton
AU - Gruber, Barry
AU - Qin, Yi Xian
N1 - Funding Information:
This work is kindly supported by the National Space Biomedical Research Institute (TD00207 & TD00405, Qin) through NASA Cooperative Agreement NCC 9-58, NIH (R01 AR49286, Qin), and US Army Medical Research and Material Command (DAMD-17-02-1-0138, Qin). We would like to thank Dr. Wei Lin, Dr. Stefan Judex, and Mr. Charles Reardon, Jr. of Stony Brook University for assistance with the DXA and uCT scanning and suggestions. The manuscript was also greatly improved by the comments of two anonymous reviewers.
PY - 2008
Y1 - 2008
N2 - Early detection of fracture risk is important for initiating treatment and improving outcomes from both physiologic and pathologic causes of bone loss. While bone mineral density (a quantity measure) has traditionally been used for this purpose, alternative structural imaging parameters (quality measures) are proposed to better predict bone's true mechanical properties. To further elucidate this, trabecular bone from cadaveric human calcanei were used to evaluate the interrelationship of mechanical and structural parameters using mechanical testing, dual energy X-ray absorptiometry (DXA) scanning, and micro computed tomography (μCT) imaging. Directional specific structural properties were assessed in three-dimensional (3-D) and correlated to mechanical testing and DXA. The results demonstrated that μCT-derived indices of bone quality (i.e., volume fraction and structural model index) are better than DXA-derived bone mineral density for the prediction of the mechanical parameters of bone (i.e., elastic modulus, yield stress, and ultimate stress). Diagnostically, this implies that future work on the early prediction of fracture risk should focus as much on bone quality as on quantity. Furthermore, the results of this study show that a loss of bone primarily affects the connectedness and overall number of trabeculae. Ultimate stress, however, is better correlated with trabecular number than thickness. As such, primary prevention of osteoporosis may be more important than later countermeasures for bone loss.
AB - Early detection of fracture risk is important for initiating treatment and improving outcomes from both physiologic and pathologic causes of bone loss. While bone mineral density (a quantity measure) has traditionally been used for this purpose, alternative structural imaging parameters (quality measures) are proposed to better predict bone's true mechanical properties. To further elucidate this, trabecular bone from cadaveric human calcanei were used to evaluate the interrelationship of mechanical and structural parameters using mechanical testing, dual energy X-ray absorptiometry (DXA) scanning, and micro computed tomography (μCT) imaging. Directional specific structural properties were assessed in three-dimensional (3-D) and correlated to mechanical testing and DXA. The results demonstrated that μCT-derived indices of bone quality (i.e., volume fraction and structural model index) are better than DXA-derived bone mineral density for the prediction of the mechanical parameters of bone (i.e., elastic modulus, yield stress, and ultimate stress). Diagnostically, this implies that future work on the early prediction of fracture risk should focus as much on bone quality as on quantity. Furthermore, the results of this study show that a loss of bone primarily affects the connectedness and overall number of trabeculae. Ultimate stress, however, is better correlated with trabecular number than thickness. As such, primary prevention of osteoporosis may be more important than later countermeasures for bone loss.
KW - Bone strength
KW - DXA
KW - Fracture
KW - Mechanical stress
KW - Microstructure
KW - Osteoporosis
KW - Trabecular bone quality
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U2 - 10.1016/j.jbiomech.2007.09.003
DO - 10.1016/j.jbiomech.2007.09.003
M3 - Article
C2 - 17953972
AN - SCOPUS:38149084050
SN - 0021-9290
VL - 41
SP - 368
EP - 375
JO - Journal of Biomechanics
JF - Journal of Biomechanics
IS - 2
ER -