Evidence-based de-implementation for contradicted, unproven, and aspiring healthcare practices

Vinay Prasad, John P.A. Ioannidis

Research output: Contribution to journalEditorialpeer-review

253 Scopus citations


Abandoning ineffective medical practices and mitigating the risks of untested practices are important for improving patient health and containing healthcare costs. Historically, this process has relied on the evidence base, societal values, cultural tensions, and political sway, but not necessarily in that order. We propose a conceptual framework to guide and prioritize this process, shifting emphasis toward the principles of evidence-based medicine, acknowledging that evidence may still be misinterpreted or distorted by recalcitrant proponents of entrenched practices and other biases.

Original languageEnglish (US)
Article number1
JournalImplementation Science
Issue number1
StatePublished - Jan 8 2014
Externally publishedYes


  • Bias
  • Contradiction
  • De-implementation
  • Divestment
  • Evidence-based medicine
  • Reversals

ASJC Scopus subject areas

  • Health Policy
  • Health Informatics
  • Public Health, Environmental and Occupational Health


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