Evidence of slow IPSP in mammalian prevertebral ganglia

R. C. Ma, N. J. Dun, Z. G. Jiang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A short train of nerve stimulation evoked in a portion of neurons of the guinea pig inferior mesenteric ganglia a slow hyperpolarization (slow IPSP) which persisted when the preceding orthodromic spikes were reduced to subthreshold EPSPs by curare, was reversibly abolished in a low Ca solution, and was not blocked by atropine; furthermore, the post-tetanic hyperpolarization induced by direct intracellular stimulation was generally smaller than the slow IPSP evoked by nerve stimulation. The slow IPSP was often associated with a fall in membrane resistance and its amplitude decreased with membrane hyperpolarization. The results indicate that the slow hyperpolarization is a synaptic potential, and differs from the slow IPSP observed in mammalian and amphibian paravertebral ganglionic neurons in that it is atropine insensitive.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalBrain research
Issue number2
StatePublished - Jul 4 1983
Externally publishedYes


  • atropine insensitive
  • prevertebral ganglia
  • slow IPSP

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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