Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

Thomas F. Kresina; Jung U. Yoo; Victor M. Goldberg

doi:10.1002/art.1780310213

Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

Thomas F. Kresina, Jung U. Yoo, Victor M. Goldberg

Orthopaedics and Rehabilitation

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following intravenous administration of antiproteoglycan monoclonal antibodies. The data support the hypothesis that autoimmunity to cartilage macromolecules may play a role in the etiopathogenesis of arthritis.

Original language	English (US)
Pages (from-to)	248-257
Number of pages	10
Journal	Arthritis & Rheumatism
Volume	31
Issue number	2
DOIs	https://doi.org/10.1002/art.1780310213
State	Published - Feb 1988

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "We examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following intravenous administration of antiproteoglycan monoclonal antibodies. The data support the hypothesis that autoimmunity to cartilage macromolecules may play a role in the etiopathogenesis of arthritis.",

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Evidence that a humoral immune response to autologous cartilage proteoglycan can participate in the induction of cartilage pathology

Abstract

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