TY - JOUR
T1 - Exercise Modalities Improve Aversive Memory and Survival Rate in Aged Rats
T2 - Role of Hippocampal Epigenetic Modifications
AU - de Meireles, Louisiana Carolina Ferreira
AU - Galvão, Fernando
AU - Walker, Deena M.
AU - Cechinel, Laura Reck
AU - de Souza Grefenhagen, Ágnis Iohana
AU - Andrade, Gisele
AU - Palazzo, Roberta Passos
AU - Lovatel, Gisele Agustini
AU - Basso, Carla Giovanna
AU - Nestler, Eric J.
AU - Siqueira, Ionara Rodrigues
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - We aimed to investigate the effects of aging and different exercise modalities on aversive memory and epigenetic landscapes at brain-derived neurotrophic factor, cFos, and DNA methyltransferase 3 alpha (Bdnf, cFos, and Dnmt3a, respectively) gene promoters in hippocampus of rats. Specifically, active epigenetic histone markers (H3K9ac, H3K4me3, and H4K8ac) and a repressive mark (H3K9me2) were evaluated. Adult and aged male Wistar rats (2 and 22 months old) were subjected to aerobic, acrobatic, resistance, or combined exercise modalities for 20 min, 3 times a week, during 12 weeks. Aging per se altered histone modifications at the promoters of Bdnf, cFos, and Dnmt3a. All exercise modalities improved both survival rate and aversive memory performance in aged animals (n = 7–10). Exercise altered hippocampal epigenetic marks in an age- and modality-dependent manner (n = 4–5). Aerobic and resistance modalities attenuated age-induced effects on hippocampal Bdnf promoter H3K4me3. Besides, exercise modalities which improved memory performance in aged rats were able to modify H3K9ac or H3K4me3 at the cFos promoter, which could increase gene transcription. Our results highlight biological mechanisms which support the efficacy of all tested exercise modalities attenuating memory deficits induced by aging.
AB - We aimed to investigate the effects of aging and different exercise modalities on aversive memory and epigenetic landscapes at brain-derived neurotrophic factor, cFos, and DNA methyltransferase 3 alpha (Bdnf, cFos, and Dnmt3a, respectively) gene promoters in hippocampus of rats. Specifically, active epigenetic histone markers (H3K9ac, H3K4me3, and H4K8ac) and a repressive mark (H3K9me2) were evaluated. Adult and aged male Wistar rats (2 and 22 months old) were subjected to aerobic, acrobatic, resistance, or combined exercise modalities for 20 min, 3 times a week, during 12 weeks. Aging per se altered histone modifications at the promoters of Bdnf, cFos, and Dnmt3a. All exercise modalities improved both survival rate and aversive memory performance in aged animals (n = 7–10). Exercise altered hippocampal epigenetic marks in an age- and modality-dependent manner (n = 4–5). Aerobic and resistance modalities attenuated age-induced effects on hippocampal Bdnf promoter H3K4me3. Besides, exercise modalities which improved memory performance in aged rats were able to modify H3K9ac or H3K4me3 at the cFos promoter, which could increase gene transcription. Our results highlight biological mechanisms which support the efficacy of all tested exercise modalities attenuating memory deficits induced by aging.
KW - Aging
KW - Bdnf
KW - Dnmt3a
KW - Exercise
KW - Histone acetylation
KW - Histone methylation
KW - Inhibitory avoidance
KW - Rats
KW - cFos
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U2 - 10.1007/s12035-019-01675-w
DO - 10.1007/s12035-019-01675-w
M3 - Article
C2 - 31250382
AN - SCOPUS:85068348699
SN - 0893-7648
VL - 56
SP - 8408
EP - 8419
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 12
ER -