EXO1-A multi-tasking eukaryotic nuclease

Phuoc T. Tran, Naz Erdeniz, Lorraine S. Symington, R. Michael Liskay

Research output: Contribution to journalReview articlepeer-review

171 Scopus citations


Exo1 was first isolated as a 5′ → 3′ exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies in several experimental systems that shed light on the role of Exo1 in these DNA transaction pathways, particularly those that may relate to oncogenesis.

Original languageEnglish (US)
Pages (from-to)1549-1559
Number of pages11
JournalDNA Repair
Issue number12
StatePublished - Dec 2 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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