Exocytosis unbound

Ko Matsui, Craig E. Jahr

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential, and there is growing evidence that neuronal exocytosis can occur from sites that are unremarkable in electron micrographs. The first discrepancy extends the dynamic range of synapses, whereas the second enables faster and more robust chemical transmission at sites distant from morphologically defined synapses. Taken together, these attributes expand the capabilities of cellular communication in the nervous system.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 2006
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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