Experimental autoimmune myocarditis in the Guinea pig

Jeffrey D. Hosenpud; Stephen M. Campbell; Mark V. Hart; Marilyn S. Paul; John R. Rowles; Nelson (Sam) Niles

doi:10.1093/cvrese/19.10.613

Experimental autoimmune myocarditis in the Guinea pig

Jeffrey D. Hosenpud, Stephen M. Campbell, Mark V. Hart, Marilyn S. Paul, John R. Rowles, Nelson (Sam) Niles

Oral Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Summary: Male and female Guinea pigs underwent immunisation with heterologous heart protein (rat heart), complete Freund's adjuvant and pertussis vaccine (immunised) or normal saline (control) at weekly intervals for 6 weeks, and were subsequently studied. In vivo intracardiac pressures, cardiac outputs, blood volumes, in vitro pressure-volume relations, left ventricular collagen contents, light microscopy, direct immunofluorescence, lymphocyte stimulation studies, and serology for circulating anti heart antibody (haemagglutination and radioimmunoassay) were performed. Immunised Guinea pigs studied between 5 and 8 weeks following the immunisation protocol demonstrated a 44% increase in LVEDP (p

Original language	English (US)
Pages (from-to)	613-622
Number of pages	10
Journal	Cardiovascular Research
Volume	19
Issue number	10
DOIs	https://doi.org/10.1093/cvrese/19.10.613
State	Published - Oct 1985

Keywords

Autoimmune
Cardiomyopathy
Myocardial dysfunction
Myocarditis

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Physiology (medical)
Physiology
Cardiology and Cardiovascular Medicine

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10.1093/cvrese/19.10.613

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AB - Summary: Male and female Guinea pigs underwent immunisation with heterologous heart protein (rat heart), complete Freund's adjuvant and pertussis vaccine (immunised) or normal saline (control) at weekly intervals for 6 weeks, and were subsequently studied. In vivo intracardiac pressures, cardiac outputs, blood volumes, in vitro pressure-volume relations, left ventricular collagen contents, light microscopy, direct immunofluorescence, lymphocyte stimulation studies, and serology for circulating anti heart antibody (haemagglutination and radioimmunoassay) were performed. Immunised Guinea pigs studied between 5 and 8 weeks following the immunisation protocol demonstrated a 44% increase in LVEDP (p

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Experimental autoimmune myocarditis in the Guinea pig

Abstract

Keywords

ASJC Scopus subject areas

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