Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure

Quin E. Denfeld, James O. Mudd, Wohaib Hasan, Jill M. Gelow, Shirin O. Hiatt, Kerri Winters-Stone, Christopher S. Lee

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear. Objective: To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF. Methods: We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores. Results: The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004). Conclusions: Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalHeart and Lung
Issue number4
StatePublished - Jul 1 2018


  • Beta-adrenergic receptor kinases
  • Biomarkers
  • G protein-coupled receptor kinase-2
  • Heart failure
  • Symptom

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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