Export of proteins across membranes: The helix reversion hypothesis

U. P. Shinde; T. N. Guru Row; Y. R. Mawal

doi:10.1007/BF01114812

Export of proteins across membranes: The helix reversion hypothesis

U. P. Shinde, T. N. Guru Row, Y. R. Mawal

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

Original language	English (US)
Pages (from-to)	737-745
Number of pages	9
Journal	Bioscience Reports
Volume	9
Issue number	6
DOIs	https://doi.org/10.1007/BF01114812
State	Published - Dec 1989
Externally published	Yes

Keywords

conformational changes
hairpin helix
leader peptides
protein export

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1007/BF01114812

Cite this

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abstract = "A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.",

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AU - Guru Row, T. N.

AU - Mawal, Y. R.

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N2 - A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

AB - A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

KW - conformational changes

KW - hairpin helix

KW - leader peptides

KW - protein export

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ER -

Export of proteins across membranes: The helix reversion hypothesis

Abstract

Keywords

ASJC Scopus subject areas

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