Export of proteins across membranes: The helix reversion hypothesis

U. P. Shinde, T. N. Guru Row, Y. R. Mawal

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

Original languageEnglish (US)
Pages (from-to)737-745
Number of pages9
JournalBioscience Reports
Issue number6
StatePublished - Dec 1989
Externally publishedYes


  • conformational changes
  • hairpin helix
  • leader peptides
  • protein export

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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