Extracellular matrix turnover and outflow resistance

Kate E. Keller, Mini Aga, John M. Bradley, Mary J. Kelley, Ted S. Acott

Research output: Contribution to journalReview articlepeer-review

187 Scopus citations


Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM). This entails sensing elevated IOP, releasing numerous activated proteinases to degrade existing ECM and concurrent biosynthesis of replacement ECM components. To increase or decrease IOP, the quantity, physical properties and/or organization of new components should be somewhat different from those replaced in order to modify outflow resistance. ECM degradation and replacement biosynthesis in the outflow pathway must be tightly controlled and focused to retain the complex structural organization of the tissue. Recently identified podosome- or invadopodia-like structures (PILS) may aid in the focal degradation of ECM and organization of replacement components.

Original languageEnglish (US)
Pages (from-to)676-682
Number of pages7
JournalExperimental Eye Research
Issue number4
StatePublished - Apr 30 2009


  • aqueous humor outflow resistance
  • biosynthetic extracellular matrix replacement
  • extracellular matrix turnover

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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