Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl

F. William Sunderman; Patricia R. Allpass; John M. Mitchell; Randall C. Baselt; Daniel M. Albert

doi:10.1126/science.104388

Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl

F. William Sunderman, Patricia R. Allpass, John M. Mitchell, Randall C. Baselt, Daniel M. Albert

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Abstract

Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

Original language	English (US)
Pages (from-to)	550-553
Number of pages	4
Journal	Science
Volume	203
Issue number	4380
DOIs	https://doi.org/10.1126/science.104388
State	Published - 1979
Externally published	Yes

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@article{96e004734699402e8f5d95cc680f4686,

title = "Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl",

abstract = "Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.",

author = "{William Sunderman}, F. and Allpass, {Patricia R.} and Mitchell, {John M.} and Baselt, {Randall C.} and Albert, {Daniel M.}",

year = "1979",

doi = "10.1126/science.104388",

language = "English (US)",

volume = "203",

pages = "550--553",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4380",

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TY - JOUR

T1 - Eye malformations in rats

T2 - Induction by prenatal exposure to nickel carbonyl

AU - William Sunderman, F.

AU - Allpass, Patricia R.

AU - Mitchell, John M.

AU - Baselt, Randall C.

AU - Albert, Daniel M.

PY - 1979

Y1 - 1979

N2 - Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

AB - Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.

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U2 - 10.1126/science.104388

DO - 10.1126/science.104388

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AN - SCOPUS:0018750621

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SP - 550

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JO - Science

JF - Science

IS - 4380

ER -

Eye malformations in rats: Induction by prenatal exposure to nickel carbonyl

Abstract

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