Facilitation and disruption of the long-term store of memory with neural excitants

John C. Crabbe; Herbert P. Alpern

doi:10.1016/0091-3057(73)90099-3

Facilitation and disruption of the long-term store of memory with neural excitants

John C. Crabbe, Herbert P. Alpern

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Male hybrid mice (C57BL/6J × DBA/2J) were trained for 2 days in a 6-unit brightness discrimination maze. Beginning 24 hr after training, mice were administered daily injections of strychnine sulphate, Metrazol, d-amphetamine sulphate, caffeine citrate, nicotine alkaloid, or saline for 5 days. Forty-eight hr after the injection series was completed, mice were trained to criterion in the maze. Mice administered strychnine sulphate or Metrazol showed significantly better retention than those administered saline while mice administered d-amphetamine sulphate were significantly poorer. Nicotine alkaloid produced a trend toward facilitation, while caffeine citrate had no effect. The observed facilitation and disruption were not due to enhancement or impairment of learning ability and could not be attributed to effects upon the consolidation process.

Original language	English (US)
Pages (from-to)	197-202
Number of pages	6
Journal	Pharmacology, Biochemistry and Behavior
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(73)90099-3
State	Published - 1973
Externally published	Yes

Keywords

Analeptics
Long-term memory store
Memory
Memory disruption
Memory facilitation
Metrazol
Pentylenetetrazol
Strychnine
d-Amphetamine

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(73)90099-3

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title = "Facilitation and disruption of the long-term store of memory with neural excitants",

abstract = "Male hybrid mice (C57BL/6J × DBA/2J) were trained for 2 days in a 6-unit brightness discrimination maze. Beginning 24 hr after training, mice were administered daily injections of strychnine sulphate, Metrazol, d-amphetamine sulphate, caffeine citrate, nicotine alkaloid, or saline for 5 days. Forty-eight hr after the injection series was completed, mice were trained to criterion in the maze. Mice administered strychnine sulphate or Metrazol showed significantly better retention than those administered saline while mice administered d-amphetamine sulphate were significantly poorer. Nicotine alkaloid produced a trend toward facilitation, while caffeine citrate had no effect. The observed facilitation and disruption were not due to enhancement or impairment of learning ability and could not be attributed to effects upon the consolidation process.",

keywords = "Analeptics, Long-term memory store, Memory, Memory disruption, Memory facilitation, Metrazol, Pentylenetetrazol, Strychnine, d-Amphetamine",

author = "Crabbe, {John C.} and Alpern, {Herbert P.}",

note = "Funding Information: Animals. The animals were 96 male F, hybrid mice, obtained from crossings between the two highly inbred strains C57BL/6J and DBA/2J. Mice which ranged in age from 85--100 days were given access to mouse chow ad lib throughout the study. Apparatus. The apparatus has been described in detail elsewhere [1 ]. The maze consisted of six discrimination units, a start box, and a goal box. The discrimination units had two parallel alleys, one painted flat black, the other flat white. The black alleys were obstructed at the distal end by a transparent window of I/8 in. standard clear vinyl. The ~This investigation was supported by National Institute of Mental Sciences Grant GM 14547. 2We wish to express our appreciation to Smith, Kline and l.'rench for supplying the d-amphetamine sulphate employed in this study.",

year = "1973",

doi = "10.1016/0091-3057(73)90099-3",

language = "English (US)",

volume = "1",

pages = "197--202",

journal = "Pharmacology, Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Facilitation and disruption of the long-term store of memory with neural excitants

AU - Crabbe, John C.

AU - Alpern, Herbert P.

N1 - Funding Information: Animals. The animals were 96 male F, hybrid mice, obtained from crossings between the two highly inbred strains C57BL/6J and DBA/2J. Mice which ranged in age from 85--100 days were given access to mouse chow ad lib throughout the study. Apparatus. The apparatus has been described in detail elsewhere [1 ]. The maze consisted of six discrimination units, a start box, and a goal box. The discrimination units had two parallel alleys, one painted flat black, the other flat white. The black alleys were obstructed at the distal end by a transparent window of I/8 in. standard clear vinyl. The ~This investigation was supported by National Institute of Mental Sciences Grant GM 14547. 2We wish to express our appreciation to Smith, Kline and l.'rench for supplying the d-amphetamine sulphate employed in this study.

PY - 1973

Y1 - 1973

N2 - Male hybrid mice (C57BL/6J × DBA/2J) were trained for 2 days in a 6-unit brightness discrimination maze. Beginning 24 hr after training, mice were administered daily injections of strychnine sulphate, Metrazol, d-amphetamine sulphate, caffeine citrate, nicotine alkaloid, or saline for 5 days. Forty-eight hr after the injection series was completed, mice were trained to criterion in the maze. Mice administered strychnine sulphate or Metrazol showed significantly better retention than those administered saline while mice administered d-amphetamine sulphate were significantly poorer. Nicotine alkaloid produced a trend toward facilitation, while caffeine citrate had no effect. The observed facilitation and disruption were not due to enhancement or impairment of learning ability and could not be attributed to effects upon the consolidation process.

AB - Male hybrid mice (C57BL/6J × DBA/2J) were trained for 2 days in a 6-unit brightness discrimination maze. Beginning 24 hr after training, mice were administered daily injections of strychnine sulphate, Metrazol, d-amphetamine sulphate, caffeine citrate, nicotine alkaloid, or saline for 5 days. Forty-eight hr after the injection series was completed, mice were trained to criterion in the maze. Mice administered strychnine sulphate or Metrazol showed significantly better retention than those administered saline while mice administered d-amphetamine sulphate were significantly poorer. Nicotine alkaloid produced a trend toward facilitation, while caffeine citrate had no effect. The observed facilitation and disruption were not due to enhancement or impairment of learning ability and could not be attributed to effects upon the consolidation process.

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KW - Long-term memory store

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KW - Memory facilitation

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KW - Strychnine

KW - d-Amphetamine

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Facilitation and disruption of the long-term store of memory with neural excitants

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Keywords

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