TY - JOUR
T1 - Factors associated with acquisition and clearance of human papillomavirus infection in a cohort of US men
T2 - A prospective study
AU - Lu, Beibei
AU - Wu, Yougui
AU - Nielson, Carrie M.
AU - Flores, Roberto
AU - Abrahamsen, Martha
AU - Papenfuss, Mary
AU - Harris, Robin B.
AU - Giuliano, Anna R.
N1 - Funding Information:
Financial support: Arizona Disease Control Research Commission (contract 7016). A.R.G. receives support from Merck and Co., the manufacturer of HPV vaccine, for the Phase III Quadrivalent HPV Vaccine Trial among Men (Tampa, Florida, site). She is also a member of the Merck Young Women’s Advisory Board and on the speaker’s bureau for Merck.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Background. Our understanding of factors associated with acquisition and clearance of human papillomavirus (HPV) in men has been limited. This study sought to determine factors associated with those aspects of HPV infection in a cohort of US men. Methods. A total of 285 men aged 18-44 years were monitored every 6 months for ∼18 months. Risk-factor information was obtained at each visit by use of a self-administered questionnaire. A continuous-time 2-state Markov model was applied. Results. Lifetime number of sex partners reported at enrollment was the most significant risk factor for acquisition of all types of HPV. Men reporting >16 lifetime sex partners were at significantly elevated risk of any HPV infection (adjusted hazard ratio [AHR], 2.8 [95% confidence interval {CI}, 1.1-7.1]), oncogenic HPV infection (AHR, 9.6 [95% CI, 2.4-37.8]), and nononcogenic HPV infection (AHR, 3.6 [95% CI, 1.3-9.9]), compared with those reporting 0-4 partners. Circumcised men were 3 and 6 times more likely to clear infection with any and oncogenic HPV types, respectively. In addition, having had >16 lifetime sex partners was associated with greater likelihood of clearance of oncogenic HPV infection (AHR, 4.9 [95% CI, 1.2-19.8]). Conclusion. The key factor associated with acquisition of HPV was lifetime number of sex partners, whereas circumcision was the most significant determinant for clearance of any HPV infection and oncogenic HPV infection.
AB - Background. Our understanding of factors associated with acquisition and clearance of human papillomavirus (HPV) in men has been limited. This study sought to determine factors associated with those aspects of HPV infection in a cohort of US men. Methods. A total of 285 men aged 18-44 years were monitored every 6 months for ∼18 months. Risk-factor information was obtained at each visit by use of a self-administered questionnaire. A continuous-time 2-state Markov model was applied. Results. Lifetime number of sex partners reported at enrollment was the most significant risk factor for acquisition of all types of HPV. Men reporting >16 lifetime sex partners were at significantly elevated risk of any HPV infection (adjusted hazard ratio [AHR], 2.8 [95% confidence interval {CI}, 1.1-7.1]), oncogenic HPV infection (AHR, 9.6 [95% CI, 2.4-37.8]), and nononcogenic HPV infection (AHR, 3.6 [95% CI, 1.3-9.9]), compared with those reporting 0-4 partners. Circumcised men were 3 and 6 times more likely to clear infection with any and oncogenic HPV types, respectively. In addition, having had >16 lifetime sex partners was associated with greater likelihood of clearance of oncogenic HPV infection (AHR, 4.9 [95% CI, 1.2-19.8]). Conclusion. The key factor associated with acquisition of HPV was lifetime number of sex partners, whereas circumcision was the most significant determinant for clearance of any HPV infection and oncogenic HPV infection.
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U2 - 10.1086/596050
DO - 10.1086/596050
M3 - Article
C2 - 19133808
AN - SCOPUS:58849160917
SN - 0022-1899
VL - 199
SP - 362
EP - 371
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -