Familial skin cancer syndromes Increased melanoma risk

Katherine J. Ransohoff, Prajaka D. Jaju, Jean Y. Tang, Michele Carbone, Sancy Leachman, Kavita Y. Sarin

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Phenotypic traits, such as red hair and freckling, increase melanoma risk by 2- to 3-fold. In addition, approximately 10% of melanomas are caused by inherited germline mutations that increase melanoma risk from 4- to >1000-fold. This review highlights the key genes responsible for inherited melanoma, with an emphasis on when a patient should undergo genetic testing. Many genetic syndromes associated with increased melanoma risk are also associated with an increased risk of other cancers. Identification of these high-risk patients is essential for preventive behavior reinforcement, genetic counseling, and ensuring other required cancer screenings.

Original languageEnglish (US)
Pages (from-to)423-434
Number of pages12
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Mar 1 2016


  • genetic syndromes
  • genetics
  • inherited cancer risk
  • melanoma
  • oncogenes
  • skin cancer
  • tumor suppressor

ASJC Scopus subject areas

  • Dermatology


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