TY - JOUR
T1 - Far-Red and Near-Infrared Seminaphthofluorophores for Targeted Pancreatic Cancer Imaging
AU - Wang, Lei
AU - Barth, Connor W.
AU - Sibrian-Vazquez, Martha
AU - Escobedo, Jorge O.
AU - Lowry, Mark
AU - Muschler, John
AU - Li, Haiyan
AU - Gibbs, Summer L.
AU - Strongin, Robert M.
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/1/31
Y1 - 2017/1/31
N2 - Molecular probes that selectively highlight pancreatic cancer (PC) tissue have the potential to improve pancreatic ductal adenocarcinoma (PDAC) margin assessment through the selective highlighting of individual PC cells. Herein, we report a simple and unique family of systematically modified red and near-infrared fluorescent probes that exhibit a field-effect-derived redshift. Two of thirteen probes distributed to the normal mouse pancreas following systemic administration. One selectively accumulated in genetically modified mouse models of PDAC. The probe exhibited intracellular accumulation and enabled visualization of four levels of the structure, including the whole organ, resected tissue, individual cells, and subcellular organelles. In contrast to the small-molecule probes reported previously, it possesses an inherent affinity toward PDAC cells and thus does not require conjugation to any targeting agent. The fluorescent probe can thus promote new strategies not only for precision image-guided surgery, but also for PC detection, monitoring of therapeutic outcomes, and basic research.
AB - Molecular probes that selectively highlight pancreatic cancer (PC) tissue have the potential to improve pancreatic ductal adenocarcinoma (PDAC) margin assessment through the selective highlighting of individual PC cells. Herein, we report a simple and unique family of systematically modified red and near-infrared fluorescent probes that exhibit a field-effect-derived redshift. Two of thirteen probes distributed to the normal mouse pancreas following systemic administration. One selectively accumulated in genetically modified mouse models of PDAC. The probe exhibited intracellular accumulation and enabled visualization of four levels of the structure, including the whole organ, resected tissue, individual cells, and subcellular organelles. In contrast to the small-molecule probes reported previously, it possesses an inherent affinity toward PDAC cells and thus does not require conjugation to any targeting agent. The fluorescent probe can thus promote new strategies not only for precision image-guided surgery, but also for PC detection, monitoring of therapeutic outcomes, and basic research.
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U2 - 10.1021/acsomega.6b00403
DO - 10.1021/acsomega.6b00403
M3 - Article
AN - SCOPUS:85028932154
SN - 2470-1343
VL - 2
SP - 154
EP - 163
JO - ACS Omega
JF - ACS Omega
IS - 1
ER -