Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

IMPACC Network; IMPACC Steering Committee; Clinical & Data Coordinating Center (CDCC); IMPACC Data Analysis Group; IMPACC Site Investigators; IMPACC Core Laboratory; IMPACC Clinical Study Team

doi:10.1038/s41467-023-44090-5

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

IMPACC Network, IMPACC Steering Committee, Clinical & Data Coordinating Center (CDCC), IMPACC Data Analysis Group, IMPACC Site Investigators, IMPACC Core Laboratory, IMPACC Clinical Study Team

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

Original language	English (US)
Article number	216
Journal	Nature communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-023-44090-5
State	Published - Dec 2024

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-023-44090-5

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IMPACC Network, IMPACC Steering Committee, Clinical & Data Coordinating Center (CDCC), IMPACC Data Analysis Group, IMPACC Site Investigators, IMPACC Core Laboratory, & IMPACC Clinical Study Team (2024). Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nature communications, 15(1), Article 216. https://doi.org/10.1038/s41467-023-44090-5

IMPACC Network, IMPACC Steering Committee, Clinical & Data Coordinating Center (CDCC), IMPACC Data Analysis Group, IMPACC Site Investigators, IMPACC Core Laboratory & IMPACC Clinical Study Team 2024, 'Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study', Nature communications, vol. 15, no. 1, 216. https://doi.org/10.1038/s41467-023-44090-5

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title = "Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study",

abstract = "Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.",

author = "{IMPACC Network} and {IMPACC Steering Committee} and {Clinical & Data Coordinating Center (CDCC)} and {IMPACC Data Analysis Group} and {IMPACC Site Investigators} and {IMPACC Core Laboratory} and {IMPACC Clinical Study Team} and Al Ozonoff and Jayavelu, {Naresh Doni} and Shanshan Liu and Esther Melamed and Milliren, {Carly E.} and Jingjing Qi and Geng, {Linda N.} and McComsey, {Grace A.} and Cairns, {Charles B.} and Baden, {Lindsey R.} and Joanna Schaenman and Shaw, {Albert C.} and Hady Samaha and Vicki Seyfert-Margolis and Florian Krammer and Rosen, {Lindsey B.} and Hanno Steen and Caitlin Syphurs and Ravi Dandekar and Shannon, {Casey P.} and Sekaly, {Rafick P.} and Ehrlich, {Lauren I.R.} and Corry, {David B.} and Farrah Kheradmand and Atkinson, {Mark A.} and Brakenridge, {Scott C.} and {Agudelo Higuita}, {Nelson I.} and Metcalf, {Jordan P.} and Hough, {Catherine L.} and Messer, {William B.} and Bali Pulendran and Nadeau, {Kari C.} and Davis, {Mark M.} and Sesma, {Ana Fernandez} and Viviana Simon and {van Bakel}, Harm and Seunghee Kim-Schulze and Hafler, {David A.} and Ofer Levy and Monica Kraft and Chris Bime and Haddad, {Elias K.} and Calfee, {Carolyn S.} and Erle, {David J.} and Langelier, {Charles R.} and Walter Eckalbar and Bosinger, {Steven E.} and Bjoern Peters and Kleinstein, {Steven H.} and Reed, {Elaine F.}",

note = "Publisher Copyright: {\textcopyright} 2024, The Author(s).",

year = "2024",

month = dec,

doi = "10.1038/s41467-023-44090-5",

language = "English (US)",

volume = "15",

journal = "Nature communications",

issn = "2041-1723",

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T1 - Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes

T2 - results from the IMPACC study

AU - IMPACC Network

AU - IMPACC Steering Committee

AU - Clinical & Data Coordinating Center (CDCC)

AU - IMPACC Data Analysis Group

AU - IMPACC Site Investigators

AU - IMPACC Core Laboratory

AU - IMPACC Clinical Study Team

AU - Ozonoff, Al

AU - Jayavelu, Naresh Doni

AU - Liu, Shanshan

AU - Melamed, Esther

AU - Milliren, Carly E.

AU - Qi, Jingjing

AU - Geng, Linda N.

AU - McComsey, Grace A.

AU - Cairns, Charles B.

AU - Baden, Lindsey R.

AU - Schaenman, Joanna

AU - Shaw, Albert C.

AU - Samaha, Hady

AU - Seyfert-Margolis, Vicki

AU - Krammer, Florian

AU - Rosen, Lindsey B.

AU - Steen, Hanno

AU - Syphurs, Caitlin

AU - Dandekar, Ravi

AU - Shannon, Casey P.

AU - Sekaly, Rafick P.

AU - Ehrlich, Lauren I.R.

AU - Corry, David B.

AU - Kheradmand, Farrah

AU - Atkinson, Mark A.

AU - Brakenridge, Scott C.

AU - Agudelo Higuita, Nelson I.

AU - Metcalf, Jordan P.

AU - Hough, Catherine L.

AU - Messer, William B.

AU - Pulendran, Bali

AU - Nadeau, Kari C.

AU - Davis, Mark M.

AU - Sesma, Ana Fernandez

AU - Simon, Viviana

AU - van Bakel, Harm

AU - Kim-Schulze, Seunghee

AU - Hafler, David A.

AU - Levy, Ofer

AU - Kraft, Monica

AU - Bime, Chris

AU - Haddad, Elias K.

AU - Calfee, Carolyn S.

AU - Erle, David J.

AU - Langelier, Charles R.

AU - Eckalbar, Walter

AU - Bosinger, Steven E.

AU - Peters, Bjoern

AU - Kleinstein, Steven H.

AU - Reed, Elaine F.

PY - 2024/12

Y1 - 2024/12

N2 - Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

AB - Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

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SN - 2041-1723

VL - 15

JO - Nature communications

JF - Nature communications

IS - 1

M1 - 216

ER -

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Abstract

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